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Diabetic Digest - November 22, 2017


So with Thanksgiving rearing its ugly head this week we've all got to stay focused and enjoy the grub within reason.

Turkey, potatoes, gravy, Oh, my! With such good eats so readily available I know I need to keep an eye on my hunger. It's okay to eat, but you can't eat it all. As much as we want to it's best to just slow your roll and have a whole long weekend of leftovers ahead of you.

Happy Thanksgiving!


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*-- Diabetic News --*

Mitochondria size vital to keeping blood sugar levels in check

NEW HAVEN, Conn. - Researchers at Yale University School of Medicine have discovered that changes in mitochondria size in brain cells plays a vital role in maintaining safe blood sugar levels.

Keeping blood sugar levels in a safe range is crucial for the management of type 1 and type 2 diabetes.

"Low blood sugar can be as dangerous as high blood sugar," Sabrina Diano, professor in the Departments of Obstetrics, Gynecology & Reproductive Sciences, Neuroscience and Comparative Medicine at Yale and senior author of the study, said in a press release. "We've found that changes in the size of mitochondria -- small intracellular organelles responsible for energy production -- in certain cells in the brain, could be key to maintaining the blood sugar within a safe range. This new finding adds to our understanding of how the body keeps blood sugar levels within a safe range when sugar levels drop, like during fasting, or when they spike after a meal."

Researchers studied mice with a specific mitochondrial protein, dynamin-related protein 1, or DRP1, that was missing or present in varying amounts in the brain cells that sense circulating sugar levels. They found that when the mouse was hungry or not, mitochondria showed dynamic changes in size and shape driven by the DRP1 protein.

"We found that when DRP1 activity in the neurons was missing, these neurons were more sensitive to changes in glucose levels," Diano said. "What surprised our research team was that these intracellular changes in this small subset of neurons were specifically important to increase blood sugar levels during a fasting period by activating the so-called counter-regulatory responses to hypoglycemia, in which the brain senses lower glucose levels and sends signals to peripheral organs such as the liver to increase glucose production."

The results show that changes in this mechanism may be crucial for the development of hypoglycemia-associated autonomic failure, a complication of diabetes treatments that happen in type 1 diabetes patients who take insulin daily for survival.

*-- Diabetic News --*


2 pounds frozen hash brown potatoes
1/2 cup melted butter
1 teaspoon salt
1/4 teaspoon pepper
1/2 cup onion, chopped
1/2 cup cream of chicken soup
1 pint sour cream with chives
2 cups grated cheddar cheese
1/2 cup celery, chopped

2 cups crushed potato chips
1/2 cup melted butter

Defrost potatoes. Combine melted butter, salt, pepper, soup and sour cream. Mix hash browns with onion, celery and cheese. Mix in soup mixture. Pour into a greased 9x12 inch casserole dish. For Topping: Mix butter and chips. Sprinkle on top of casserole. Bake in a 350 degree oven for 45 minutes or until topping is golden brown.

Yield: 16 Servings
Categories: Potatoes, Casseroles


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