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Diabetic Digest - March 29, 2017


I've been dealing with a head cold for a week or so and it's been playing havoc with my blood-sugar. It seems no matter how much or how little insulin or food I consume my numbers are sky-high.

The good thing is that this only happens when I'm sick so it's the ultimate confirmation. This usually happens before the signs of illness show themselves - so I can brace myself for what's to come.

Don't you hate spring colds?


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*-- Diabetic News --*

Diabetes drug may protect against deadly form of breast cancer

Researchers in China have discovered a metabolic enzyme inhibitor called epalrestat, used to treat complications from diabetes, could be effective in fighting a deadly form of breast cancer.

The metabolic enzyme AKR1B1 promotes the growth of the deadly form of basal-like and triple-negative breast cancer.

Between 15 and 20 percent of all breast cancers are basal-like, which is particularly aggressive and falls into the triple-negative breast cancer subtype. Currently, there are no effective treatments for this form of breast cancer, which is often fatal.

Basal-like breast cancer is more aggressive due to a process called epithelial-mesenchymal transition, or EMT, a process where cancer cells become more capable of motion and gain stem cell-like properties allowing them to resist treatment and metastasize.

Researchers discovered levels of AKR1B1 were significantly higher in basal-like and triple-negative breast cancers, which was linked to increased rates of metastasis and death.

Conversely, researchers found that knocking down AKR1B1 inhibited the growth and metastasis of tumors in basal-like breast cancer cells injected into mice.

The study also revealed epalrestat, a drug used to treat peripheral diabetic neuropathies, inhibits AKR1B1 and can block the growth and metastasis of basal-like breast cancer cells.

"Our data clearly suggests that AKR1B1 overexpression represents an oncogenic event that is responsible for the aggressive behaviors of basal-like breast cancer cells," Chenfang Dong, a researcher at the Zhejiang University School of Medicine in Hangzhou, China, said in a press release. "Since epalrestat is already on the market and has no major adverse side effects, our study provides a proof of principle that it could become a valuable targeted drug for the clinical treatment of basal-like breast cancer."

The study was published in The Journal of Experimental Medicine.

*-- Diabetic News --*


2 cups chopped fresh tomatoes
1 cup fresh or canned tuna, shredded
1/4 cup very thinly julienned basil leaves
1 cup cubed fresh (packed in water) mozzarella cheese
1 cup cooked sweet corn
1/4 small red onion, thinly sliced
1/4 cup olive oil
1/3 cup balsamic vinegar
salt and pepper to taste

Mix it all together, toss well and let sit in the fridge for about an hour. Serve with bread or over butter lettuce.

Categories: Salad


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