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Friday, June 11th, 2010
Protein may help repair MS brain damage
ST. LOUIS - U.S. scientists say they've found a protein that
helps build the brain in infants might help in restoring
brain damage caused by neurodegenerative diseases. Using a
mouse model of multiple sclerosis, researchers at Washington
University School of Medicine in St. Louis said they found
the protein CXCR4 is essential for repairing myelin, a pro-
tective sheath that covers nerve cell branches. MS and other
disorders damage myelin, and that damage is linked to loss
of the branches inside the myelin. "In MS patients, myelin
repair occurs inconsistently for reasons that aren't clear,"
said Dr. Robyn Klein, an associate professor of medicine and
neurobiology and the study's senior author. "Understanding
the nature of that problem is a priority because when myelin
isn't repaired, the chances that an MS flare-up will inflict
lasting harm seem to increase." The research that included
postdoctoral fellow Jigisha Patel is detailed in the early
online edition of The Proceedings of the National Academy of
Sciences.
Researchers find more autism genetic links
TORONTO - Autism may be caused by rare changes in a person's
genome that are not inherited and are unique to each case, a
study suggests. Published in the journal Nature on Wednesday,
the study says each autistic person may have a unique pat-
tern of genetic changes occurring along common biological
pathways, the Canadian Broadcasting Corp. reported. Research
found people with autism tended to have either missing or
extra copies of segments of DNA known as copy number vari-
ants, which can disrupt how genes work. The variants identi-
fied in the study "may broaden the targets amenable to gene-
tic testing and therapeutic intervention," its authors said.
"By identifying the genetic causes of autism," Tony Monaco
of Oxford University's Wellcome Trust Center for Human Gene-
tics said, "we hope in the future to be able to improve the
diagnosis and treatment of this condition which can affect
children and their families so severely." Stephen Scherer
of the Hospital for Sick Children in Toronto said the re-
sults could "lead to a paradigm shift when it comes to
understanding the root causes of autism," CBC reported.
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Major discovery made in prostate cancer
PARIS - A French-led international team of scientists says
it has discovered how polyphenols in red wine and green tea
inhibit prostate cancer growth. The scientists -- who say
their finding might lead to a major advance in the treatment
of prostate cancer -- said they discovered antioxidants in
red wine and green tea disrupt an important cell-signaling
pathway necessary for prostate cancer growth. The research-
ers, led by the French National Institute of Health and Med-
ical Research in Paris, said their findings that appear in
the early online edition of The FASEB Journal, might lead to
the development of drugs that could stop or slow cancer
progression, or improve current treatments. "Not only does
(the) signaling pathway play a role in prostate cancer, but
it also plays a role in other cancers, such as colon cancer,
breast cancer and gastric cancers," said Dr. Gerald, editor-
in-chief of The FASEB Journal. In the experiment, three
groups of mice were given drinking water, drinking water
with a green tea compound known as EGCg, or drinking water
with a different green tea compound, polyphenon E. Then
human prostate cancer cells were implanted in the mice. The
results showed a dramatic decrease in tumor size in the mice
drinking the green tea mixtures. "The profound impact the
antioxidants in red wine and green tea have on our bodies is
more than anyone would have dreamt just 25 years ago,"
Weissmann said. "As long as they are taken in moderation,
all signs show that red wine and green tea may be ranked
among the most potent 'health foods' we know."
Updated HIV therapy guidelines endorsed
VANCOUVER, British Columbia - Canadian scientists say they've
determined adherence to updated HIV therapy guidelines would
result in increased benefits for patients and society in gen-
eral. Researchers from the British Columbia Center for Excel-
lence in HIV/AIDS and the University of British Columbia say
their mathematical modeling study of the 2008 International
AIDS Society-USA therapy guidelines for treatment of the
human immunodeficiency virus shows full implementation would
lead to more people entering treatment, an increase in lives
saved, billions of dollars in costs averted and a significant
decrease in infections. "The study results are critically
important because they reinforce the significant individual
and societal benefits of starting earlier HIV treatment and
provide further momentum for treatment as prevention, which,
in the absence of a vaccine or cure, remains the best way to
contain and halt the spread of HIV," said Dr. Julio Montaner,
director of the center. The research appears in the online
journal PLoS One.
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Quit smoking post-surgery, help healing
STOCKHOLM, Sweden - Patients who avoid tobacco for six weeks
after surgery for a fracture have fewer post-operative compli-
cations, researchers in Sweden found. Dr. Hans Nasell, senior
surgical consultant at Karolinska Institutet in Stockholm,
Sweden, said earlier research indicated quitting smoking
prior to surgery resulted in better healing and fewer post-
operative complications. In this study, conducted at three
Stockholm hospitals, daily smokers who had emergency surgery
for an acute fracture were offered a six-week smoking ces-
sation program within two days of surgery. The smoking
cessation program included one or two in-person meetings,
regular telephone contact with a nurse trained in the ces-
sation program and free nicotine substitution. Before this
study, many physicians thought patients needed to stop
smoking prior to surgery to gain any benefit, Nasell said.
"It was surprising, and encouraging, to see that even
stopping smoking following surgery for a period of time can
offer significant benefits, including nearly a 50 percent
reduction in wound complications," Nasell said in a state-
ment. "The smoking cessation program requires only about 2
to 3 hours of support from the nursing staff, which is sig-
nificantly less time than would be required for the treatment
of side effects such as poor wound healing which can occur
as a side effect of smoking." The study is published in The
Journal of Bone and Joint Surgery.
Study: Combo melanoma therapy ineffective
PITTSBURGH - A U.S. study suggests a combination of two
chemotherapies and a previously approved treatment for kidney
and liver cancers is not effective against melanoma. "With
each new study, we learn something important about the treat-
ment of melanoma," said Dr. John Kirkwood, a professor at the
University of Pittsburgh School of Medicine who led the re-
search. "With this study, we learned that the addition of
sorafenib, a molecular inhibitor, to a traditional chemo-
therapy regimen does not improve patient survival." The 34
month, phase III trial involved 823 patients from seven
different U.S. sites. Patients either received the chemo-
therapy combination alone or with sorafenib. "While this
study didn't confirm the very promising results of phase II
studies with sorafenib, it is important to share its findings
since the double chemotherapy combination of carboplatin and
paclitaxel has achieved results that eclipse previous chemo-
therapy results in large phase III trials," Kirkwood said.
"These results take us one step closer to understanding how
to most effectively treat metastatic melanoma." Melanoma is
a form of skin cancer that causes most skin-cancer-related
deaths. Only two therapies have been approved by the U.S.
Food and Drug Administration for treatment of advanced mela-
noma, and neither has been shown to prolong survival. The
research was presented Saturday in Chicago during the annual
meeting of the American Society of Clinical Oncology.
--------------- Health Tip Video of the Week ---------------
Dr. Mom: Caring for Elders
Rating: 3.95
Caring for a parent can be tough on anyone. Doctor Mom has
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your loved ones get the great care they deserve.
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