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Friday, May 7th, 2010
Chlamydia-induced arthritis therapy found
TAMPA, Fla. - Scientists say a multicenter international
clinical trial's findings suggest a combination of antibi-
otics effectively treats Chlamydia-induced arthritis. Dr. -
John Carter of the University of South Florida College of
Medicine led the National Institutes of Health-sponsored
investigation and said the findings represent a major step
toward management, and possibly cure, of the disease. "Our
findings lend hope that eradication of this persistent in-
fection is attainable and a possible cure exists," said
Carter, an associate professor of medicine. The scientists
said reactive arthritis, also known as Reiter's syndrome,
is an autoimmune disorder that develops in response to an
infection elsewhere in the body. That type of arthritis is
most commonly caused by the bacteria Chlamydia trachomatis,
usually acquired through sexual contact, or Chlamydia pneum-
oniae, which can trigger respiratory infection. The research
team devised a new prolonged course of combination antibiotic
treatment, which attacked two different pathways that allow
Chlamydia infection to persist in the joints. The double-
blind, placebo-controlled trial involved 42 patients randomly
assigned to one of three treatment groups -- rifampin plus
doxycycline, rifampin plus azithromycin, or placebo. The
researchers said patients treated with the combination anti-
biotics improved significantly more in measures of the
swelling and tenderness of joints and symptom assessment.
The trial that included the Louisiana State Health Science
Center, the University of Toronto and Wayne State University
appears in the journal Arthritis & Rheumatism.
Prostate cancer drugs under safety review
WASHINGTON - The U.S. Food and Drug Administration announced
Monday it is reviewing the safety of several commonly used
prostate cancer drugs. The FDA said a preliminary review
suggests an increase in the risk of diabetes and certain
cardiovascular diseases in men treated with gonadotropin-
releasing hormone agonists. "GnRH agonists are drugs that
suppress the production of testosterone, a hormone that is
involved in the growth of prostate cancer," the FDA said.
"This type of treatment is called androgen deprivation
therapy. Suppressing testosterone has been shown to shrink
or slow the growth of prostate cancer." The drugs under
review are Lupron, Trelstar, Eligard, Synarel, Vantas, Viadur
and Zoladex. Officials said the medications have been
associated with a small increased risk of diabetes, heart
attack, stroke and sudden death in men. Based on those
initial findings, the FDA said it believes healthcare pro-
fessionals should be aware of the potential risks and care-
fully weigh the benefits and risks of GnRH agonists when
determining a treatment for patients with prostate cancer.
However, the FDA said patients should not stop treatment
unless instructed to do so by a healthcare professional.
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Study: MicroRNA involved in lung fibrosis
PITTSBURGH - U.S. medical investigators say they've deter-
mined MicroRNAs appear to play a significant role in the
development of idiopathic pulmonary fibrosis. Researchers
led by Associate Professor Naftali Kaminski at the the Uni-
versity of Pittsburgh School of Medicine said MicroRNAs are
short strands of genetic material involved in regulating the
expression, or activity, of genes. They are a new family of
RNA molecules thought to be factors in embryonic development,
multiple cancers and chronic heart failure. "Our research
now indicates that microRNA changes also contribute to IPF,"
Kaminski said. "We have identified an entirely new molecular
mechanism for the disease, which gives us new ideas about
how to treat it." The study that included scientists in
Greece, Mexico and Germany appears in the American Journal
of Respiratory and Critical Care Medicine.
Nanoscience may help cancer researchers
BETHESDA, Md. - Scientists say a U.S. government project is
making progress in finding ways to use nanotechnology to im-
prove diagnosis, treatment and prevention of cancer. Piotr
Grodzinski and colleagues at the National Cancer Institute's
Alliance for Nanotechnology in Cancer say the $145 million
project is producing innovations that will radically improve
care for the disease. Grodzinski says the alliance builds on
more than 50 years of advances in cancer care that, although
substantial, still leave cancer as the No. 1 cause of death
worldwide. The researchers, in an update of the status of
the program, describe a range of advances, including some
showing significant promise in clinical trials that would
have a big impact on cancer. They promise earlier disease
diagnosis, highly targeted treatments that kill cancer cells
but leave normal cells alone, fewer side effects and improved
survival. The report appears in the American Chemical Society
journal Nano.
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Some steroid meds may help tissue repair
DURHAM, N.C. - Duke University medical researchers say
they've found some commonly used steroid medications might
aid in tissue-repairing regenerative therapy. The steroid
hormone called glucocorticoids is usually used for asthma
inflammation and skin injury. But the scientists said they
determined during studies on cells from mice, the drugs
appeared to promote and protect stem cell populations that
perform tissue repair. "We found that these common compounds
could help to produce populations of (nerve-repairing)
neuronal stem cells and may even have a protective effect
on the new stem cells, which could assist in tissue repair
processes," said Assistant Professor Wei Chen, the study's
senior author. "Next we would like to study how these drugs
work in specific conditions, starting with spinal cord in-
jury repair and neural regeneration in the setting of
Parkinson's disease." The study that included Associate
Professor Larry Barak and researchers Jiangbo Wang, Jiuyi
Lu, Michael Bond, Minyong Chen and Xiurong Ren appears in
the early online edition of the Proceedings of the National
Academy of Sciences.
New genes linked to osteoporosis
MONTREAL - An international team of scientists, including
some from Canada, has linked 20 genes with osteoporosis,
including 13 never before associated with the disease. Re-
searchers at the Jewish General Hospital in Montreal and
colleagues said osteoporosis is a highly heritable trait,
but the study marks the largest international effort to
conclusively identify genes linked to the often-devastating
bone disorder. Dr. J. Brent Richards collaborated with more
than 30 co-authors worldwide in reviewing data collected
from nearly 20,000 individuals in five recent international
genetic studies. "Hip fractures are a common and costly
condition which has a 50 percent mortality rate at two
years, worse than some cancers," Richards, an assistant
professor at McGill University, said. "Not only did we find
13 entirely new genes, we also demonstrated that some of
these genes were related not just to bone density, but also
to fracture risk itself." He said the findings will allow
scientists to better study the genetic mechanisms that
control bone strength, and to intervene to prevent peoples'
bones from becoming weak. "Also, if we are able to uncover
more genes which influence bone strength, then we may be
able to identify whole populations that require early pre-
ventive treatment," he added. The research was reported
recently in the journal Nature Genetics.
--------------- Health Tip Video of the Week ---------------
Treating Prostate Cancer
Rating: 3.56
A diagnosis of prostate cancer is scary - but this form of
cancer is usually treatable. Watch this video to learn more
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