Amazing Reunion Between Lion & Human - As Seen on The View
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Friday, April 23rd, 2010


Possible nano treatment for acne created

SAN DIEGO - A U.S. bioengineer says she has created a pos-
sible new acne treatment that uses nanotechnology to deliver
the therapy directly to skin-dwelling bacteria. University
of California-San Diego graduate student Dissaya Pornpat-
tananangkul said she, along with Professor Liangfang Zhang,
developed a "smart delivery system" that uses nanotechnology
to deliver lauric acid -- a natural product found in both
coconut oil and human breast milk -- directly to the bac-
terium propionibacterium, which causes common acne. "It's a
good feeling to know that I have a chance to develop a drug
that could help people with acne," Pornpattananangkul said.
The new delivery system includes gold nanoparticles attached
to surfaces of lauric-acid-filled "nano-bombs." The scien-
tists said the gold nanoparticles keep the nano-bombs --
artificially made microscopic sacs into which the lauric
acid can be packaged -- from fusing together. The nanopart-
icles also help the liposomes locate acne-causing bacteria
based on the skin's microenvironment, including pH. Once
the liposomes reach the bacterial membranes, the acidic
microenvironment causes the gold nanoparticles to drop off,
allowing the lauric acid to kill the bacteria. The research
appeared in the March edition of the journal Nano.


New leukemia treatment target suggested

COLUMBUS, Ohio - U.S. medical researchers say they have
identified a group of molecules that keep acute leukemia
cells alive and, therefore, might be a treatment target. Ohio
State University scientists said their findings suggest a new
strategy for treating acute myeloid leukemia as well as
lowering the amount of a protein called KIT. They said they
discovered a network of protein and microRNA molecules that,
when imbalanced, contribute to abnormal KIT protein abun-
dance. That, in turn, favors leukemia development, they said.
"We now understand the mechanism responsible for making so
much KIT protein in AML cells, and we believe that targeting
that mechanism and reducing the amount of that protein will
prove to be a more effective therapy for this disease than
the current standard of care," said Dr. Guido Marcucci, a
professor of internal medicine who co-led the study. "Our
study suggests that the amount of KIT protein in cancer
cells is as important as its activity, and we discovered
that the amount of the protein is controlled by a circular
network of molecules that has many points of entry," co-
leader Dr. Ramiro Garzon said. "These findings provide a
strong rationale for the use and development of drugs that
target the components of this network, rather than focusing
on the activity of KIT alone." The research appears in the
April 13 issue of the journal Cancer Cell.

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FDA to look at use of home medical devices

WASHINGTON - The U.S. Food and Drug Administration says it's
starting an initiative to ensure caregivers and patients
safely use complex medical devices in their homes. The FDA
said hemodialysis equipment, intravenous therapy devices and
ventilators are among medical products that have migrated
into homes in recent years. And more hospital patients of
all ages are being discharged to continue their medical
treatment at home. "Using complex medical devices at home
carries unique challenges," said Dr. Jeffrey Shuren, director
of the FDA's Center for Devices and Radiological Health.
"Caregivers may lack sufficient training, product instruc-
tions may be inadequate or overly technical, and the home
environment itself may pose environmental or safety hazards
that can affect the product's functioning." The federal
agency said its initiative will develop guidance for manu-
facturers who intend to market a device for home use, provide
for postmarket surveillance and put in place other measures
to encourage safe use of such devices. The FDA said it's also
working to strengthen home health agency accreditation cri-
teria that relate to medical device safe use practices.


New drug target found for Alzheimers

CHAMPAIGN, Ill. - U.S. scientists say they've identified a
potential drug target for Alzheimer's disease -- a receptor
embedded in the membrane of neurons and other cells. The
University of Illinois researchers led by Professors Kevin
Xiang and Charles Cox said a protein fragment associated
with Alzheimer's disease -- amyloid-beta protein -- activates
a receptor called the AMPA receptor, increasing activity in
the affected neurons and eventually leading to cell death. In
the study, the researchers focused on the beta-2 adrenergic
receptor, a protein that -- like the AMPA receptor -- resides
in the cell membrane. Neurotransmitters and hormones normally
activate the beta-2 adrenergic receptor, but amyloid-beta
also induces a cascade of events in the neurons when it does
so, the researchers found. Cox said the receptor offers an
attractive alternative target because amyloid-beta binds to
a different part of the receptor than that normally engaged
by neurotransmitters and hormones. That, said the scientists,
means it might be possible to stop amyloid-beta from binding
to it without hindering the other functions of the beta-2
adrenergic receptor. Xiang and Cox said the beta-2 adrenergic
receptor is almost certainly not the only important player
in the damage that occurs in an Alzheimer's-afflicted brain.
But they see it as a promising new potential target for
future drug research.

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New therapy for advanced prostate cancer

NEW YORK - U.S. cancer researchers say an experimental drug
is providing effective targeted therapy in treating an
aggressive form of advanced prostate cancer. Memorial Sloan-
Kettering Cancer Center scientists said a new multicenter
study suggests the drug -- MDV3100 -- is safe and effective
for patients with castration-resistant prostate cancer.
Such cancers are known for their poor prognosis and limited
treatment options. The scientists said the combined Phase 1
and 2 study found MDV3100 not only shrank patients' tumors,
but also reduced serum levels of the tumor marker prostate-
specific antigen, stabilized disease that had spread to
soft tissues and the bone, and reduced the number of circu-
lating tumor cells in the blood. "We were encouraged to see
anti-tumor activity in men whose disease had spread to other
parts of the body after either becoming resistant to previous
hormone treatments or progressing following chemotherapy,"
said Dr. Howard Scher, chief of the Sloan-Kettering's
Genitourinary Oncology Service and the study's lead author.
"These findings strengthen the drug's potential to change
the outlook for a group of patients who currently have
limited effective treatment options from which to choose."
The study appears online, ahead of print, in The Lancet.


Added sugar can increase heart attack risk

ATLANTA - Added sugars -- especially in processed foods and
beverages -- may increase heart disease risk factors, U.S.
researchers said. Study co-author Dr. Miriam Vos, assistant
professor of pediatrics at Emory School of Medicine, and
colleagues analyzed nutritional data and blood lipid (fat)
levels in more than 6,000 adult men and women from 1999 to
2006. The highest-consuming study subjects ate an average
of 46 teaspoons of added sugars per day, while the lowest-
consuming study subjects are an average of just 3 teaspoons
daily. The study, published in the Journal of the American
Medical Association, found those who ate more added sugar
were more likely to have higher cardiovascular disease risk
factors -- including higher triglyceride levels and higher
ratios of triglycerides to high-density lipoprotein, the
"good" cholesterol. "Just like eating a high-fat diet can
increase your levels of triglycerides and high cholesterol,
eating sugar can also affect those same lipids," Vos said in
a statement. "It would be important for long-term health
for people to start looking at how much added sugar they're
getting and finding ways to reduce that."



--------------- Health Tip Video of the Week ---------------

Kick Carpal Tunnel To the Curb

Rating: 4.27

Carpal Tunnel Syndrome is a waking nightmare, but an
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