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Friday, March 12th, 2010
Optimistic lung cancer patients do better
ROCHESTER, Minn. - U.S. researchers say they've discovered
lung cancer patients who have an optimistic disposition ex-
perience more favorable outcomes than pessimistic patients.
Previous research into how the body communicates with the
mind has demonstrated a connection between pessimistic out-
look and negative health behaviors. The current study, sci-
entists said, builds on existing research to gain knowledge
specifically toward the effect of attitudes on lung cancer
patients. The researchers said their retrospective study
identified pessimistic and non-pessimistic or optimistic
personality styles and found patients classified as having
an optimistic attitude survived an average of six months
longer compared with patients demonstrating a pessimistic
attitude. Five-year survival rates for the two groups were
32.9 percent for non-pessimists and 21.1 percent for pessi-
mists. Furthermore, the relationship was independent of
smoking status, cancer stage, treatment, co-morbidities, age
and gender. "This six-month potential benefit related to an
optimistic attitude is more impressive when one considers
that the median survival time for this patient population
with lung cancer is less than one year," said lead investi-
gator Paul Novotny of the Mayo Clinic. The research appears
in the Journal of Thoracic Oncology.
Food allergy disorder linked to gene
CINCINNATI - U.S. medical investigators say they have linked
a food allergy-related disorder to a so-called master allergy
gene. Researchers led by Dr. Marc Rothenberg at Cincinnati
Children's Medical Center Hospital report identifying a
region of a human chromosome that is associated with eosino-
philic esophagitis, often called EoE, a recently recognized
allergic disease. The scientists said people suffering EoE
frequently have difficulty eating or may be allergic to one
or more foods, with symptoms varying with age; In children a
major symptom is vomiting, while in older children food might
become stuck in the esophagus. The study suggests a suspected
so-called master allergy gene might play a role in the
development of the rare, but debilitating, disorder. The
researchers, supported by the National Institute of Allergy
and Infectious Diseases and the National Institute of Dia-
betes and Digestive and Kidney Diseases, performed a genome-
wide association analysis in children with EoE and healthy
children. The investigators identified changes in genes with-
in a region on chromosome 5 that were highly associated with
EoE, with one gene that encodes a protein called thymic
stromal lymphopoietin found more highly expressed in children
with the condition than in children without the disorder. The
researchers said the gene might be a master switch that turns
on other allergic diseases, such as asthma and atopic derma-
titis. The study appears in the journal Nature Genetics.
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Nanoparticles target specific cancer cells
ITHACA, N.Y. - U.S. scientists say they have created synth-
esized nanoparticles that can identify, target and kill
specific cancer cells while leaving healthy cells alone.
Cornell University researchers led by Professor Carl Batt
said the nanoparticles are made of gold sandwiched between
two pieces of iron oxide. Antibodies that target a molecule
found only in colorectal cancer cells is then attached. Once
bound, the nanoparticles are engulfed by the cancer cells.
To kill the cells, the researchers said they used a near-
infrared laser, which is a wavelength that doesn't harm nor-
mal tissue at the levels used. But the radiation is absorbed
by the gold in the nanoparticles. That causes the cancer
cells to become heated and die. "This is a so-called 'smart'
therapy," Batt said. "To be a smart therapy, it should be
targeted, and it should have some ability to be activated
only when it's there and then kills just the cancer cells."
The goal, said lead author and biomedical graduate student
Dickson Kirui, is to improve the technology and make it suit-
able for testing in a human clinical trial. The researchers
are now working on a similar experiment targeting prostate
cancer cells. The research appeared in the Feb. 15 online
edition of the journal Nanotechnology.
Moderate caffeine may not hurt heart
SAN FRANCISCO - U.S. researchers say it is unlikely moder-
ate caffeine increases heart arrhythmia risks. Researchers
at the Kaiser Permanente Division of Research in Oakland,
Calif., found those who reported drinking four or more cups
of coffee daily had an 18 percent lower risk of hospitali-
zation for heart rhythm disturbances and those drinking one
to three cups each day had a 7 percent lower risk. "Coffee
drinking is related to lower risk of hospitalization for
rhythm problems, but the association does not prove cause
and effect, or that coffee has a protective effect," lead
author Dr. Arthur Klatsky said in a statement. "However,
these data might be reassuring to people who drink moderate
amounts of coffee that their habit is not likely to cause a
major rhythm disturbance." Klatsky and colleagues looked at
130,054 men and women, ages 18-90 -- with the majority age
50 and younger. About 2 percent -- 3,317 participants -- were
hospitalized for rhythm disturbances. Fourteen percent in
the study drank less than one cup of coffee a day, 42 percent
drank one to three cups of coffee a day, 17 percent reported
drinking four cups or more each day and about 27 percent
were not coffee drinkers. The findings were presented at a
conference of the American Heart Association held in San -
Francisco.
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Method found to grow unlimited stem cells
NEW YORK - U.S. scientists say they've devised a method that
uses blood vessel cells to grow unlimited amounts of adult
stem cells. In what's described as a leap toward making stem
cell therapy widely available, researchers at the Ansary Stem
Cell Institute at Weill Cornell Medical College say they've
discovered endothelial cells that line various body cavities
produce growth factors that can grow copious amounts of adult
stem cells within just a few weeks. The researchers said
until now, adult stem cell cultures would die within four or
five days despite any efforts to grow them. "This is ground-
breaking research with potential application for regeneration
of organs and inhibition of cancer cell growth," said Dr. -
Antonio Gotto Jr., dean of the Weill Cornell Medical College.
Professor Shahin Rafii, co-director of the stem cell insti-
tute, said the study will have a major impact on the treat-
ment of any blood-related disorder that requires a stem cell
transplant. "We are the first group to demonstrate that
endothelial cells elaborate a repertoire of stem-cell-active
growth factors that not only stimulate stem cell expansion,
but also orchestrate differentiation of these stem cells into
their mature progeny," added Dr. Jason Butler, a senior in-
vestigator at Weill Cornell Medical College and first author
of the study. The research appears in the January issue of
the journal Nature Reviews Cancer and in the Jan. 17 issue
of Nature Biotechnology.
Cardiac catheterization revisions urged
DURHAM, N.C. - Some U.S. cardiologists say it is time to
revise the criteria used to select patients for cardiac
catheterization. The Duke University Medical Center invest-
igators, led by Dr. Manesh Patel, said their study deter-
mined the invasive procedure finds no significant coronary
artery disease in nearly 60 percent of chest-pain patients
with no prior heart disease. The researchers said more than
10 million people experience chest pain each year and many
undergo cardiac catheterization, which is the U.S. standard
care for people who experience heart attack or unstable chest
pain. The procedure allows doctors to confirm the presence,
location and severity of coronary atherosclerosis. "We're
spending a lot of energy and money to evaluate chest pain
which often leads to cardiac catheterization, which, we now
know, often finds that patients don't have significant
obstructive disease," Patel said. What is needed, he said,
is a re-evaluation of the entire decision-making process of
caring for patients with chest pain, including how patients'
histories are taken, how risk factors are assessed and the
role of diagnostic testing. The research appears in the New
England Journal of Medicine.
--------------- Health Tip Video of the Week ---------------
Obesity and Gastric Bypass
Rating: 5
Obesity is our number one health problem. Here is the
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