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Friday, February 26, 2010
New technique may help melanoma patients
COLUMBIA, Mo. - U.S. scientists say the use of laser-induced
ultrasound could help physicians locate the general area of
a lymph node where melanoma cells might reside. University
of Missouri researchers said knowing the stage of a patient's
melanoma is important when choosing the best course of treat-
ment. When the cancer has progressed to the lymph nodes, a
more aggressive treatment is needed, but examining an entire
lymph node for cancer takes much effort and time. The laser-
induced ultrasound technique could help doctors identify the
stage of melanoma with more accuracy and speed. "This method
can be used to determine if the cancer has spread from stage
2, where the melanoma is still just in the skin lesion, to
stage 3, where the melanoma has spread to the lymph nodes,"
said Assistant Professor John Viator. "If the cancer is still
at stage 2, a simple procedure can remove that lesion. If
the cancer has progressed from the initial skin lesion into
the lymphatic region and possibly the bloodstream, doctors
have to make serious decisions about patient care." In the
study, Viator took human cancer cells and placed them inside
canine lymph nodes. Then, using the laser, he determined the
best ways to locate the cancer cells. The next step, he said,
is to try the procedure using human lymph nodes. The research
is reported in Journal of Biomedical Engineering.
Advance reported in hepatitis C therapy
DURHAM, N.C. - U.S. scientists say they've found two genetic
alterations linked to an enzyme deficiency that may help
patients remain anemia-free during hepatitis C therapy.
Researchers at Duke University's Institute for Genome
Sciences & Policy say many people undergoing treatment for
hepatitis C develop hemolytic anemia, a disorder that
destroys red blood cells. In some cases, it is so severe
they have to reduce their medication or stop therapy
altogether. But the scientists say their latest discovery
opens the door to treatment for patients who have never been
considered candidates for therapy, and the finding might
also hold the key to new drugs that could prevent anemia
from developing in the first place. The research is detailed
in the early online edition of the journal Nature.
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FDA concerned about HIV drug combination
WASHINGTON - The U.S. Food and Drug Administration says pre-
liminary study data suggest Invirase used with Norvir in HIV
therapy might have adverse effects on the heart. The FDA
said when used together, Invirase (saquinavir) and Norvir
(ritonavir) might cause a reaction in the heart that can
lead to an abnormal heart rhythm, which, in turn, can pro-
gress to a life-threatening irregular heart beat known as
ventricular fibrillation. Invirase, an antiretroviral medi-
cation first approved in 1995, is used in combination with
Norvir and other antiretroviral medicines to treat the human
immunodeficiency virus in adults, officials said. Invirase
is marketed by Genentech, a subsidiary of the Roche Group.
Norvir is marketed by Abbott Laboratories.
Robotic kidney surgery has good outcomes
WINSTON-SALEM, N.C. - A Wake Forest University Baptist Med-
ical Center study shows robot-assisted kidney surgery is
faster and has better outcomes. Dr. Ashok Hemal, a urologic
surgeon, compared laparoscopic and robot-assisted surgery
for repairing blockages that prevent urine from draining
normally into the bladder. The researchers followed the pat-
ients for 18 months and determined both options were equally
successful, but the robot-assisted technique had several
advantages. On average, robot-assisted surgery was 50 per-
cent faster, resulted in 60 percent less blood and required
a two-day hospital stay, versus 3.5 days for laparoscopic
surgery. "This was one of the first studies where a single
surgeon at one center performed both types of surgery and
compared the results," said Hemal, director of the Robotic
and Minimally Invasive Urologic Surgery Program at Wake
Forest Baptist. "It allows for a more accurate comparison
of surgical options than multiple physicians performing the
surgeries. The results showed that robot-assisted surgery
had significant advantages for this condition. It is also
generally easier for surgeons to learn." The research, which
included Drs. Satyadip Mukherjee and Kaku Singh at the All
India Institute of Medical Sciences in New Delhi, is re-
ported in the Canadian Journal of Urology.
Hearing loss twice as likely with diabetes
WEST PALM BEACH, Fla. - People with diabetes are twice as
likely to have hearing loss as those who do not have dia-
betes, a U.S. audiologist says. Dr. Cindy Beyer, an audio-
logist and senior vice president of HearUSA, a hearing care
and hearing aids company, says the National Institutes of
Health landmark study, published in the Annals of Internal
Medicine, recommended that all men and women with diabetes
have their hearing tested. "Based on the findings of the
NIH study, 5 million Americans living with diabetes also
have hearing loss that, in many cases, remains undetected
and untreated," Beyer says in a statement. Untreated
hearing loss is serious. Studies have linked untreated
hearing loss to fatigue, stress and depression, avoidance
of social situations, reduced job performance and earning
power, and diminished health, Breyer says. All HearUSA
company-owned hearing care centers in New York state will
be offering free hearing-loss screenings, along with a free
80-minute "Living With Diabetes" video produced by the
American Diabetes Association, to anyone with diabetes
during the month of March.
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FDA reviews Avandia safety data
WASHINGTON - The U.S. Food and Drug Administration says it
is reviewing data from a long-term study concerning possible
cardiovascular risks with the drug Avandia. The FDA's
announcement follows a Saturday report from the U.S. Senate
Finance Committee that showed a link between the type 2
diabetes drug and thousands of heart attacks. But the FDA
said its review of the clinical trial, as well as several
observational studies of Avandia (rosiglitazone), are on-
going "and no new conclusions or recommendations about the
use of rosiglitazone in the treatment of type 2 diabetes
have been made at this time." The federal agency said it
plans to present all new and existing cardiovascular safety
data on the drug during a July public meeting, as well as
an updated assessment of the risks and benefits of rosiglita-
zone in the treatment of type 2 diabetes. "The FDA recommends
healthcare professionals follow the recommendations in the
drug label when prescribing rosiglitazone. This includes a
Boxed Warning," the FDA said in a statement. "Patients should
continue taking rosiglitazone unless told by their healthcare
professional to stop." Avandia is manufactured by
GlaxoSmithKline.
Memory in Alzheimer's mouse model revived
SAN ANTONIO - University of Texas Health Science Center
researchers say they have successfully reversed Alzheimer's-
like memory deficits in a mouse model of the disease. The
researchers, led by Assistant Professor Salvatore Oddo, said
they used rapamycin -- a drug that keeps the immune system
from attacking transplanted organs -- in rescuing the
learning and memory deficits. Oddo said the study offers
the first evidence the drug might be valuable in treating
Alzheimer's patients. Oddo said rapamycin also reduced
Alzheimer's-like lesions in the brains of the mice. "Our
findings may have a profound clinical implication," Oddo
said. "Because rapamycin is a U.S. Food and Drug Admin-
istration-approved drug, a clinical trial using it as an
anti-Alzheimer's disease therapy could be started fairly
quickly." Last year three institutions, including the Uni-
versity of Texas' Barshop Institute for Longevity and Aging
Studies, announced rapamycin extended the lifespan of aged
research mice. That was the first pharmacologic intervention
shown to extend life in an animal model of aging. Rapamycin,
a bacterial product first isolated in soil from the island
Rapa Nui in the South Pacific, also is being tested in cancer
research studies, scientists said. "While it remains to be
determined whether our results obtained in mice could be
translated in people, we are very excited as these findings
may lead to a new therapeutic intervention to treat
Alzheimer's," Oddo said. The study is reported in the Journal
of Biological Chemistry.
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