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Friday, December 18, 2009

Worm study may help epilepsy treatments

TUSCALOOSA, Ala. - U.S. scientists who used worms in a study
of epilepsy say their results might lead to new drugs tar-
geted to resolve epileptic seizures. University of Alabama
researchers said they used transparent roundworms (C.elegans)
to help them identify key "molecular switches" that control
the transport of a molecule called gamma-aminobutyric acid,
or GABA, that, if manipulated within our cells, might pre-
vent the onset of seizures. "It is our hope that this work
serves to accelerate the path toward the identification of
genetic factors that cause a susceptibility to epilepsy,"
said Associate Professor Guy Caldwell, co-author of the
study, "Simultaneously, this work has the potential to
uncover new avenues toward therapeutic development to con-
trol or prevent seizures in the future." The research is
detailed in the journal Genetics.


A new target found for lymphoma therapy

BOSTON - U.S. cancer researchers say they've found a link
between a common mutation that can lead to cancer and a
distant gene regulator that enhances its activity. The
Children's Hospital Boston scientists say their discovery
could lead to drugs targeting B-cell lymphomas, including
Burkitt's lymphoma, an aggressive cancer in children, as
well as multiple myelomas and other blood-related cancers.
Lymphomas often originate in B cells, the scientists said
-- the same cells that produce antibodies to help fight
infections. B cells can become cancerous if a gene known
as c-myc leaps to another section of DNA -- the IgH region,
responsible for building antibodies -- fuses with it, and
somehow becomes over-activated. The researchers said scien-
tists have wondered for years how that oncogenic activation
occurs, in particular what component in the IgH region act-
ivates c-myc. The new study not only identifies the regu-
latory component, but marks the first time researchers are
able to understand how that movement of genes, or "chrom-
osomal translocation," can hijack a B cell's operation
badly enough to lead to cancer. "IgH-to-myc translocation
is the classic example of activation of an oncogene in
cancer," says Frederick Alt, senior author of the study.
"But nobody really understood how it works." The complex
research is reported in the journal Nature.

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Hormone leptin tied to lower Alzheimer's

BOSTON - High levels of the hormone leptin have been linked
to lower rates of Alzheimer's disease, researchers in Boston
have discovered. The researchers at Boston University say if
confirmed, their findings, which appear in The Journal of the
American Medical Association, could prove important in the
hunt for effective prevention and treatment of Alzheimer's,
WebMD reported Tuesday. Leptin, which is produced by fat
cells, is considered critical for regulating hunger and
weight. The body of evidence is growing that it also plays
a role in brain development and memory. Research shows leptin
reduces concentrations of B-amyloid, the major component of
the deposits, or plaques, that occur in the brains of people
with Alzheimer's. The latest study of 785 elderly people
found that after 12 years of follow-up, those with the lowest
leptin levels were roughly four times more likely than those
with the highest levels to develop Alzheimer's disease. "Our
study raises a strong possibility that leptin may actually
have a role in the various pathological processes that result
in clinical Alzheimer's disease," Dr. Sudha Seshadri, a
senior researcher at Boston University School of Medicine,
told WebMD.


New nanoparticle might find, treat cancer

HOUSTON - U.S. scientists say they've created a nanoparticle
that might be able to allow both cancer diagnosis and treat-
ment during one hospital visit. Rice University and Baylor
College of Medicine researchers said their single nanopart-
icle can be tracked in real time with magnetic resonance
imaging as it homes in on cancer cells, tags them with a
fluorescent dye and then kills them with heat. "Some of the
most essential questions in nanomedicine today are about
biodistribution -- where particles go inside the body and
how they get there," said study co-author Professor Naomi
Halas. "Non-invasive tests for biodistribution will be en-
ormously useful on the path to FDA approval, and this tech-
nique -- adding MRI functionality to the particle you're
testing and using for therapy -- is a very promising way of
doing this." The new research that included graduate student,
Rizia Bardhan and Baylor Assistant Professor Amit Joshi
appears online in the journal Advanced Functional Materials.

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Scientists move closer to HIV vaccine

PHILADELPHIA - U.S. medical scientists say they are one step
closer to developing a vaccine against the AIDS virus. Sci-
entists at Thomas Jefferson University in Philadelphia, led
by Professor Matthias Schnell, director of the Jefferson
Vaccine Center, say they have determined a rabies virus-
based vaccine administered to monkeys protected them against
the simian equivalent of the human immunodeficiency virus.
The researchers previously showed a rabies-based vaccine
expressing HIV and simian immunodeficiency virus antigens
was protective against a chimeric HIV-SIV in monkeys. In
their study, the researchers said they used highly attenuated
rabies virus vaccine vectors to protect against a challenge
with highly pathogenic SIV. That type of SIV causes a more
similar disease in monkeys compared with human infection with
HIV-1. In addition, it is difficult to protect monkeys
against an AIDS-like disease after challenge with SIVmac251.
"Although we can't yet block the infection, we showed that
we can protect against disease," said Schnell. "We also saw
significant antibody activity against the virus, which is
promising. In addition, this is a very simple approach that
only took two immunizations." The data were reported in the
journal Vaccine.


Lab finds 89 wrong results in cancer tests

QUEBEC CITY, Quebec - Of nearly 3,000 breast cancer test re-
sults for Quebec women, a U.S. lab found 89 of them were
incorrect, the provincial health minister said Wednesday.
At a news conference, Minister of Health Yves Bolduc said 39
of the women incorrectly diagnosed required a change in their
treatments, the Globe and Mail reported. Of those 39, five
have since died, Bolduc said. He said the families of the
dead women will be informed of the findings. Bolduc said
regardless of treatment, 25 percent of women diagnosed with
breast cancer die each year. The province paid $800,000 to
Pheno-Path Laboratories in Seattle to re-test 2,856 samples
after provincial pathologists raised concerns of discrepan-
cies in the laboratory tests conducted on breast cancer
patients. There is a move afoot by former cancer patients in
the province to file a class-action suit over alleged im-
proper treatment, the newspaper said.


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