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Thursday, November 12, 2009
FDA approves treatment for rare cancer
WASHINGTON - The U.S. Food and Drug Administration says it
has approved a new treatment for patients with a rare form
of cancer known as Cutaneous T-cell Lymphoma. The FDA says
it has approved the use of Istodax (romidepsin), an inject-
able medication for the slow-growing cancer of infection-
fighting white blood cells called T-lymphocytes. Most cases
start with dry skin, red rash and itching that can become
severe. The skin may develop tumors that can become ulcer-
ated, causing infection. In some cases, Cutaneous T-cell
Lymphoma spreads to the blood, lymph nodes, or internal
organs. FDA officials said Istodax interferes with processes
required for cell replication. It is intended to be used in
patients when the cancer becomes worse or returns after at
least one other type of chemotherapy has been used. "This
approval demonstrates FDA's commitment to the development
and approval of drugs for rare and uncommon diseases," said
Dr. Richard Pazdur, director of the FDA's Office of Oncology
Drug Products. Istodax is marketed by Gloucester Pharmaceut-
icals Inc. of Cambridge, Mass.
Penile tissue implants deemed success
WINSTON-SALEM, N.C. - U.S. researchers say they have been
able to grow new penile tissue in labs and implant it into
rabbits to restore their sexual function. Dr. Anthony Atala,
director of the Institute for Regenerative Medicine at Wake
Forest University Baptist Medical Center in North Carolina,
says the technique could has the potential to be used to
treat severe erectile dysfunction in men, Healthday News
reported Tuesday. "We were able to show the tissue was able
to integrate and function in the long term, which means we
can start planning clinical applications (in humans)," Atala
told Healthday. "Our hope is to be able to treat patients
with many conditions, including congenital abnormalities of
the penis, traumatic injuries, penile cancer and severe cases
of erectile dysfunction that don't benefit from drug treat-
ments." The news service said the result of the study was
published in the Nov. 9 online edition of the Proceedings of
the National Academy of Sciences. Atala said the implanted
penile tissue reconstituted itself when implanted into rab-
bits, forming new blood vessel structures necessary for
erections while nerves from the existing tissue integrated
themselves into the new tissue.
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Nanomedicine may help spinal cord injuries
WEST LAFAYETTE, Ind. - Purdue University scientists say
they've developed a technique that uses nanomedicine to help
repair damaged spinal cord nerve fibers. The researchers say
their new approach involves injecting nanospheres into the
bloodstream shortly after an accident. The synthetic "copo-
lymer micelles" are drug-delivery spheres about 60 nanometers
in diameter, or roughly 100 times smaller than the diameter
of a red blood cell. Although micelles have been used rout-
inely to deliver drugs in various therapies, the Purdue
researchers say they've demonstrated the micelles themselves
repair damaged axons -- fibers that transmit electrical im-
pulses in the spinal cord. "That was a very surprising dis-
covery," Associate Professor Ji-Xin Cheng, who led the study,
said. "Micelles have been used for 30 years as drug-delivery
vehicles in research, but no one has ever used them directly
as a medicine." The scientists said micelles might be used
instead of more conventional "membrane sealing agents,"
including polyethylene glycol, which makes up the outer shell
of the micelles. Because of the nanoscale size and the poly-
ethylene glycol shell of the micelles, they are not quickly
filtered by the kidney or captured by the liver, enabling
them to remain in the bloodstream long enough to circulate to
damaged tissues. The study is detailed in the journal Nature
Nanotechnology.
Study finds how to stop some cancer growth
COLD SPRING HARBOR, N.Y. - U.S. scientists say they might
have found a way to stop the growth of certain aggressive
tumors for which there are currently no treatments. Cold
Spring Harbor Laboratory researchers in New York say more
than half of human cancers have mutations that disable a
gene called p53. When cells lose that gene, tumors grow
aggressively. But a research team led by Associate Professor
Alea Mills says it's discovered a way of stopping the growth
of such cancers. The scientists said their technique involves
turning up the production of TAp63 proteins, which make up
one class of proteins produced by the p63 gene. The TAp63
proteins completely blocked tumor initiation by inducing
senescence, a state of growth arrest in which tumor cells
are still metabolically alive, but fail to divide. The scien-
tists said they also discovered that by increasing the levels
of TAp63 in cells that did not have p53, they blocked the
progression of established tumors in mice. "We were very
excited to see that TAp63 shuts down cancer completely in-
dependently of p53," Mills said. "This means that we now
have a way of attacking cancers that have damaged p53, which
are very difficult to treat in the clinic." The study appears
in the journal Nature Cell Biology.
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Head injuries driving new helmet designs
WASHINGTON - Only longtime use will determine whether new
football helmet designs protect the brain against dangerous
concussions, head injury experts said. An estimated 1.6 -
million to 3.8 million recreation-related concussions are
sustained annually in the United States, many of them on
football fields. Football helmet makers are redesigning their
products in hopes of providing protection against both rou-
tine and extreme blows, The Washington Post reported Tuesday.
Adams is lining its helmets with foam of varying degrees of
density, while Riddell is marketing a helmet that sends a
wireless alert to a team's training staff when a player takes
a potentially dangerous hit. Xenith is marketing the X1, a
helmet with air-cushioned shock absorbers. While the rede-
signed helmets show promise, they still can't stop a player's
brain from rattling inside the skull like a scrambled yolk
inside a raw egg, said Dave Halstead of the National Oper-
ating Committee on Standards for Athletic Equipment, an
independent group that certifies helmets. "Anyone who says
to you that they have a helmet that eliminates concussions
is lying to you," Halstead told the Post.
PET imaging useful in lung cancer cases
PHILADELPHIA - U.S. scientists say a rapid decline in meta-
bolic activity on a PET scan after radiation for non-small
cell lung cancer suggests good local tumor control. PET
scanning, or Positron Emission Tomography, is an imaging
technique that produces a 3-D image of the body's functional
processes, according to Wikipedia. It can also provide an
image of tissue metabolic activity. In addition, the re-
searchers said they also found the higher the metabolic
activity and tumor size on a PET scan before treatment,
the more likely a patient is to die from lung cancer. "PET
scanning is an emerging tool of molecular imaging in lung
cancer, in contrast to CT scans and MRI scans which are
anatomic imaging," said Thomas Jefferson University Associate
Professor Maria Werner-Wasik, the study's lead author. "It
has become an important tool in the evaluation of lung can-
cer staging and evaluation of treatment response." Werner-
Wasik and colleagues conducted a retrospective analysis of
50 patients with lung cancer who received PET imaging before
and after radiation therapy, focusing on the prognostic fac-
tors for tumor local failure. Their detailed findings were
presented last week in Chicago during the annual meeting of
the American Society for Therapeutic Radiology and Oncology.
--------------- Health Tip Video of the Week ---------------
Kick Carpal Tunnel To the Curb (Workplace Health Tip)
Rating: 4.11
Carpal Tunnel Syndrome is a waking nightmare, but an avoid-
able one! Check out these easy tips for easing the pain
associated with this condition.
http://www.evtv1.com/player.aspx?itemnum=12470
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