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Friday, June 4th, 2010
Study finds alternative to antibiotics
HAMILTON, Mont. - A U.S. National Institutes of Health-led
study has created what's described as a possible future
alternative to the use of antibiotics to prevent infection.
Researchers from the National Institute of Allergy and
Infectious Diseases, Colorado State University and Juvaris
Biotherapeutics of Burlingame, Calif, developed a treatment
that protects mice from infection with the bacterium that
causes tularemia, a highly infectious disease of rodents,
sometimes transmitted to people and also known as rabbit
fever. In additional experiments, scientists say they also
demonstrated protection against three other types of
disease-causing bacteria that, like the tularemia bacterium,
occur naturally, can be highly virulent and are considered
possible agents of bioterrorism. The experimental treatment
works by stimulating the host's immune system to destroy
invading microbes, the NIH said. In contrast, antibiotics
work by directly attacking invading bacteria, which often
develop resistance to these medications. The therapeutic
has the potential to enhance the action of antibiotics and
provide an alternative to them. The research, led by
Catharine Bosio at NIAID's Rocky Mountain Laboratories in
Hamilton, Mont., appears online in the journal PLoS Patho-
gens.
New treatment found for abnormal heartbeat
DALLAS - U.S. medical investigators say they've found a new
treatment known as a visually guided balloon-laser catheter
stops abnormal heartbeats in people and pigs. The scientists
said severe cases of irregular heartbeat may require a pro-
cedure called ablation, which destroys a group of "misfiring"
cells to stop abnormal electrical impulses that cause er-
ratic heartbeats. In the clinical trial the scientists said
they aimed at cells in the pulmonary veins that carry blood
from the lungs to the heart. They said they ablated the mis-
firing cells with 100 percent accuracy. In 84 percent of the
pulmonary veins treated, electrical pulses ceased after just
one set of laser treatments. Three months after treatment,
90 percent of the treated veins remained inactive. Unlike
other catheters that rely on X-rays for visual guidance,
the new procedure involves the use of a slender instrument
called an endoscope that provides continuous real-time
images. That allows investigators to aim the laser at pre-
cise locations in the pulmonary veins. For the animal model,
the scientists examined pigs because their hearts are similar
to human hearts. The investigators inactivated abnormally
functioning pulmonary veins 97 percent of the time after the
first set of laser-energy treatments. Four weeks later, 80
percent of the ablated veins were still inactive. The re-
searchers said additional studies are needed to determine
the long-term safety and efficacy of the new procedure.
The study is reported in the journal Circulation: Arrhythmia
and Electrophysiology.
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New thyroid cancer therapy: Longer life
ROCHESTER, Minn. - U.S. cancer scientists say they've discov-
ered aggressive treatment of anaplastic thyroid cancer can
dramatically increase survival rates. Mayo Clinic oncologists
say the new approach reflects the need to aggressively treat
metastasis even when the rare cancer seems to be confined to
the neck. Historically, anaplastic thyroid cancer has been
treated with surgery and radiation, but due to rapid spread
of microscopic cancer, only up to 20 percent of patients
survive more than a year. Because the prognosis for this
cancer is so poor, Mayo physicians felt a more aggressive
pilot approach that added earlier chemotherapy was merited.
Of 24 patients with newly diagnosed anaplastic thyroid cancer
seen at Mayo Clinic between 2003 and 2007, 10 patients with
local disease elected to pursue the aggressive approach.
After surgery, the patients were treated with intensity modu-
lated radiation therapy and with aggressive chemotherapy in
efforts to simultaneously control disease in the neck and
forestall metastasis. One-year survival in the group was 70
percent, with six of the 10 patients alive at least two
years post-treatment -- five of them without evidence of
disease. Two of those patients were treated more than three
years ago and are still in remission. The study -- led by
Drs. Keith Bible Robert Foote and Julian Molina -- is to be
presented in Chicago during the annual meeting of the Amer-
ican Society of Clinical Oncology.
New contact dermatitis test developed
MORGANTOWN, W.Va. - U.S. scientists say they've created a
fast, inexpensive test for chemicals that can cause contact
dermatitis and one that does not require the use of animals.
The new test can determine whether chemicals in consumer
products and at workplaces might cause skin allergies in
people. Itai Chipinda and his colleagues at the National
Institute for Occupational Safety and Health in Morgantown,
W.Va., sought such a test because of rising public sentiment
against the use of animals to determine whether ingredients
in consumer soaps, shampoos and other products might cause
skin sensitization and contact dermatitis. Existing chemical
tests use substances such as glutathione that mimic skin
proteins and bond to allergy-causing ingredients. None, how-
ever, is suitable for use in detecting the critical early
stages of skin sensitization, the scientists said. Instead
of glutathione, Chipinda and his team developed a test with
nitrobenzenethiol as the skin protein surrogate. When used
on 20 chemicals known to cause skin irritation, the test
produced positive results. It produced negative results when
used to test substances that usually do not produce skin
sensitization. "This simple, rapid and inexpensive absorbance-
based method has great potential for use as a preliminary
screening tool for skin allergens," the researchers said.
The findings appear in the journal Chemical Research in
Toxicology.
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Study seeks earlier Alzheimer's diagnosis
BETHESDA, Md. - The U.S. National Institutes of Health is
funding a $24 million study that seeks to identify brain
changes that might signal future Alzheimer's disease. Vol-
unteers are now being sought for the two-year clinical study
examining the subtle changes that may occur in the brains
of older people many years before overt symptoms of Alz-
heimer's disease appear. Researchers are looking for people
with the very earliest complaints of memory problems that
affect their daily activities. "The study will follow
participants over time, using imaging techniques developed
to advance research into changes taking place in the struc-
ture and function of the living brain, as well as biomarker
measures found in blood and cerebrospinal fluid," the NIH
said. Researchers said they want to recruit 200 volunteers
between the ages of 55 and 90 who may be transitioning from
normal cognitive aging to an early stage of amnestic mild
cognitive impairment -- a condition that can progress to
Alzheimer's disease. Participants may volunteer at 51 sites
across the United States. To volunteer or learn more about
the study people can contact the Alzheimer's Disease Edu-
cation and Referral Center at 800-438-4380. Volunteers must
speak English or Spanish and have a person willing to assist
them during at least five clinic visits and with telephone
contacts from researchers.
FDA OKs new osteoporosis treatment
WASHINGTON - The U.S. Food and Drug Administration says it's
approved an injectable therapy for postmenopausal women with
osteoporosis who are at high risk for fractures. The FDA
said the drug, Prolia, works to decrease the destruction of
bone and increase bone mass and strength. An injection of
Prolia is recommended once every six months. Osteoporosis is
a disease in which the bones become weak and are more likely
to break. The National Institute of Arthritis and Musculo-
skeletal and Skin Diseases says 80 percent of the people in
the United States with osteoporosis are women and one of
every two women over age 50 will break a bone during their
lifetime due to osteoporosis. Prolia is manufactured by Amgen
Manufacturing Ltd., a subsidiary of Amgen Inc. of Thousand
Oaks, Calif.
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