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Thursday, October 22, 2009
Study looks at malaria parasite genetics
BALTIMORE - U.S. scientists say they've found creation of a
broadly protective malaria vaccine may be difficult due to
genetic differences in most malaria parasites. Researchers
at the University of Maryland School of Medicine's Center
for Vaccine Development said they charted the extreme gen-
etic differences that occur over time in the most dangerous
malaria parasite in the world. The findings, the scientists
said, suggest developing a broadly protective vaccine for
malaria might be challenging because the parasite's genetic
makeup is so variable and constantly changing. If a vaccine
targets only a single protein in the parasite, and there are
many different versions of that protein, the parasite becomes
a moving target for vaccine development. Drug-resistant mal-
aria has been a major barrier to treating the disease, and
the new study suggests "vaccine-resistant" malaria might also
become a problem. The research led by Assistant Professor
Shannon Takala appears in the journal Science Translational
Medicine.
Gardasil OK'd to stop male genital warts
WASHINGTON - The U.S. Food and Drug Administration says it
has approved the use of the vaccine Gardasil to prevent male
genital warts due to the human papillomavirus. The FDA said
it approved Gardasil (condyloma acuminata) to stop warts
caused by HPV in boys and men ages 9-26 years. Genital warts
are diagnosed annually in approximately 2 of every 1,000 men
in the United States, the federal agency said. The FDA prev-
iously approved Gardasil for use in girls and women ages 9-26
for the prevention of cervical, vulvar and vaginal cancer
caused by HPV, as well as pre-cancerous lesions and genital
warts. HPV is the most common sexually transmitted infection
in the United States and most genital warts are caused by HPV
infection. "This vaccine is the first preventive therapy
against genital warts in boys and men ages 9 through 26, and,
as a result, fewer men will need to undergo treatment for
genital warts," said Dr. Karen Midthun, acting director of
the FDA's Center for Biologics Evaluation and Research.
Gardasil is manufactured by Merck and Company Inc. of White-
house Station, N.J.
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Doctors: How to avoid Halloween horrors
DALLAS - A U.S. emergency doctor advises parents to check
and see if their children's Halloween costume's swords,
knives and wands are flexible with dulled edges. Dr. Angela
Gardner, president of the American College of Emergency
Physicians, says Halloween horrors ending in the hospital
emergency room might be prevented if adults take some pre-
cautions. "Halloween should be about good times and fun
with friends and family, yet sadly, each year we see kids
who are injured while trick-or-treating," Gardner says in
a statement. Gardner advises parents to avoid other costume
hazards, such as baggy pants, long hems, high heels or over
sized shoes that cause tripping, vision-obstructing headgear
and fabrics, wigs, or beards made of flammable materials.
Candle-lit Jack-O-Lanterns should be kept away from children
so the kids -- or their costumes -- aren't burned. Other
ways to avoid Halloween horrors include:
-- Adding reflective tape to costumes to increase visibility
and carrying flashlights while trick-or-treating.
-- Having children stay off streets and on the sidewalks as
much as possible.
-- Making sure candy not in its original wrapper and all
fruit are thrown away.
FDA OK's pediatric seasonal flu vaccine
WASHINGTON - The U.S. Food and Drug Administration says it
has approved the seasonal influenza vaccine Fluarix for use
in children ages 3 years to 17 years. The FDA said Fluarix,
which contains inactivated influenza A and B viruses, had
previously been approved for use in adults. The drug is a
seasonal influenza vaccine and is not intended to protect
against the 2009 H1N1 flu virus, officials said. "The safety
and effectiveness of Fluarix for use in children ages 3 years
and older is documented by a U.S. study comparing 2,115
children who received Fluarix with 1,210 children who re-
ceived Fluzone, a different influenza vaccine already lic-
ensed by the FDA for use in children ages 6 months and
older," the FDA said. "Study results showed that children 3
years and older vaccinated with Fluarix and Fluzone produced
similar amounts of antibodies in the blood at levels consid-
ered likely to be protective against seasonal influenza."
Because Fluarix contains a small amount of egg protein, it
should not be administered to anyone allergic to eggs or egg
products, officials said. Fluarix is manufactured by Glaxo-
SmithKline Biologicals of Dresden, Germany.
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Study: Gene protects against breast cancer
WASHINGTON - U.S. scientists say drugs being tested for
treatment of a variety of allergies, asthma and autoimmune
diseases might lead to the development of breast cancer.
Georgetown University Medical Center researchers said some
drugs now in clinical trials work by suppressing the activity
of a gene called SYK. Because that gene protects people from
breast cancer, researchers say its inhibition might inadvert-
ently promote the development of breast tumors. The scien-
tists said they found the gene and its protein product are
crucial for prevention of breast cancer in mice and human
breast cells they studied. That research, they said, is the
most definitive yet to demonstrate the beneficial function
of the SYK protein as a tumor suppressor. "Years of research
has led us to believe that (the protein) is important in
breast cancer, but we still need to find out why and when
some women lose function," Professor Susette Mueller, who
led the study, said. "In the meantime, we can only voice
concern that inhibiting the protein may have unfortunate
consequences." The findings are reported in the online jour-
nal PLoS One.
Math model diagnoses ER heart failure
TORONTO - Canadian medical scientists say they have devel-
oped a mathematical model that more accurately diagnoses
acute heart failure in hospital emergency rooms. Researchers
at St. Michael's Hospital in Toronto say their accomplishment
-- the first mathematical model in cardiology and emergency
medicine -- more quickly and reliably diagnoses acute heart
failure in emergency room patients, allowing physicians to
diagnose the condition with greater accuracy. "Our model aims
to ensure early correct diagnosis and treatment, which allows
for shorter emergency department stay for these patients and
could lead to improved health outcomes and better access to
precious emergency department resources," Dr. Brian Stein-
hart, who led the study, said. The research that included
physicians at Massachusetts General Hospital and the Harvard
Medical School in the United States is reported in the Jour-
nal of the American College of Cardiology.
--------------- Health Tip Video of the Week ---------------
Hydrocodone with Ibuprofen (Vicoprofen)
Rating: 3.77
A pharmacist explains how Vicoprofen works, why doctors
prescribe this pain killer, and common side effects of the
drug. This video is part of a large series on prescription
medications.
http://www.evtv1.com/player.aspx?itemnum=8655
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