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Friday, December 25, 2009
Vaccine blocks malaria transmission
TOKYO - A nasal vaccine that blocked transmission of malaria
from mice to mosquitoes someday could prevent malaria in
people, scientists in Japan said. The experimental vaccine,
which contained parasite antigens, blocked the ookinete-to-
oocyst phase in the malarial life cycle in which the malarial
parasite is fertilized in the mosquito's body, the scientists
wrote in the December issue of the journal Infection and
Immunity. Mosquitoes that stung and sucked blood from the
nasally vaccinated mice were unable to pass malaria to other
living beings because the fertilization cycle had been inter-
rupted. Children in developing countries often are at high
risk of infection and death from Malaria. Antimalarial drugs
and insecticide-treated bed nets have reduced the rate of
malaria, but vaccines are needed for eradication of the in-
fectious disease, the American Society for Microbiology said.
People can trick mind to do hated things
CHICAGO - People tend to approach pleasure and avoid pain,
but humans can trick the mind into doing beneficial things
they don't like, U.S. researchers suggest. Aparna A. Labroo
of the University of Chicago and Jesper Nielsen of the Uni-
versity of Arizona in Tucson say human inclination is to
avoid -- or try to avoid -- anything immediately aversive
even though it may be beneficial for us in the long term.
"We tend to infer that something is good based on the bodily
sensation of approaching it or bad based on the sensation of
avoiding it," the researchers say in a statement. However,
the authors demonstrate an approach often used to try to
cure phobic patients -- asking them to mentally simulate
approaching the objects they fear -- can also create more
favorable evaluations of "yucky" products and behaviors. The
researchers offered study respondents a can of curried grass-
hopper -- not terribly popular among the participants -- and
asked one group to simply evaluate it, a second group to
mentally simulate physical avoidance of the product and a
third to simulate physical approach toward the can. "What
was surprising was that merely simulating physical approach
resulted in a more favorable evaluation of the product," the
authors say in a statement. "One way for us to overcome
aversions is to trick our minds." The findings are published
in the Journal of Consumer Research.
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Gene therapy useful in emphysema
BOSTON - A new gene therapy involving a single treatment
could prevent the progression of inherited emphysema, sci-
entists in Boston said. Using mice, researchers at Boston
University School of Medicine prevented the progression of
Alpha-1 Anti-trypsin Deficiency, the most common inherited
form of emphysema seen in young people, the university said
in release. People who inherit the deficiency are predisposed
to early emphysema and cirrhosis of the liver. The research-
ers were able to deliver therapeutic genes to as much as 70
percent of a mouse lung's alveolar macrophages, a cell type
that contributes to emphysema. The lung macrophages carrying
the therapeutic genes survived in the lung air sacks for the
two-year lifetime of the mice and significantly improved the
health of the mice, said Dr. Darrell Kotton, an associate
professor of medicine and pathology who led the study.
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Effects of binge drinking linger
PROVIDENCE, R.I. - Heavy drinking adversely affects a
person's performance and perception hours after alcohol has
left the body, researchers in Rhode Island said. Researchers
at Brown University recruited 95 healthy adults ages 21 to
35 who had reported having a hangover at least one time
within the month before the research began. The participants
were randomly assigned bourbon or vodka and told to drink
until their breath tests indicated a blood alcohol level of
0.11 percent, well over the legal driving limit for most
states, Medpage Today reported Tuesday. After eight hours
of sleep and breakfast, the participants showed poorer
performance in simulated driving tests than participants who
had consumed only cola with several drops of alcohol the
night before. "We found that people were impaired in their
ability to do tasks that require both vigilance and making
rapid decisions and that people were not aware that their
performance was impaired," researcher Damaris Rohsenow told
Medpage Today.
New antiviral effective against bird flu
MADISON, Wis. - A compound tested in mice has proved safer
and more effective against H5N1 bird flu than the popular
antiviral Tamiflu, scientists in Wisconsin said. T-705 even
works after several days of infection, said Yoshihiro
Kawaoka, a virologist at the University of Wisconsin's
School of Veterinary Medicine. "H5N1 virus is so pathogenic
even Tamiflu doesn't protect all the infected animals,"
Kawaoka said. "This (antiviral) compound works much better,
even three days after infection." T-705 has been tested
successfully against bird flu and H1N1 swine flu in mouse
experiments and is being tested on humans in Japan against
seasonal flu, Kawaoka said in the Proceedings of the
National Academy of Sciences. Some scientists believe bird
flu, which is extremely difficult to treat, could spread
worldwide, though so far cases have been isolated to Asia.
T-705 targets the viral molecule polymerase, an enzyme that
enables the virus to copy its genetic material. By disabling
polymerase, the virus can't create new virus particles
needed to maintain the chain of infection, Kawaoka said in
a release Tuesday.
--------------- Health Tip Video of the Week ---------------
Knee Injuries 101
Rating: 3.43
One sick day is fun - a week's worth may not be. An injury
to the vital knee joint can keep you at home and horizontal
for days, but it helps to know what may be causing that pain.
Watch to find out.
http://www.evtv1.com/player.aspx?itemnum=8495
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