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Thursday, November 20, 2009
Sebelius: Mammogram policies unchanged
WASHINGTON - The Obama administration says its mammogram
policy is unchanged despite a U.S. panel's finding that
routine tests aren't necessary for women in their 40s. U.S.
Health and Human Services Secretary Kathleen Sebelius Wed-
nesday distanced the administration from a report issued by
the U.S. Preventive Services Task Force, a 16-member panel
assembled by the agency, which recommended that women under
50 forgo routine breast cancer tests and instead get mammo-
grams individually in consultation with their doctors, The
Washington Post reported. The panel said frequent mammograms
for younger women cause more problems than they catch because
of the anxiety caused by false positive results, the news-
paper said. But Sebelius said the task force's conclusions
have "caused a great deal of confusion and worry among women
and their families across this country" and noted that "they
do not set federal policy and they don't determine what
services are covered by the federal government. "Keep doing
what you have been doing for years -- talk to your doctor
about your individual history, ask questions, and make the
decision that is right for you," Sebelius said.
FDA approves new post-shingles attack drug
WASHINGTON - The U.S. Food and Drug Administration says it
has approved a medicated skin patch that relieves the pain
associated with shingles. The FDA said the Qutenza (cap-
saicin) 8 percent patch treats pain that occurs after a
shingles attack -- post-herpetic neuralgia. Shingles is an
outbreak of rash or blisters produced by the same virus that
causes chickenpox. Officials said anyone who once had chick-
enpox is at risk of shingles. PHN is a condition affecting
nerve fibers that can cause excruciating pain, the FDA said.
Up to 15 percent of patients who suffer shingles experience
PHN and the complication is even more common in elderly pat-
ients. Qutenza contains capsaicin, a compound found in chili
peppers. Although there are over-the-counter products avail-
able with lower concentrations of capsaicin, Qutenza is the
first pure, concentrated, synthetic capsaicin-containing pre-
scription drug to undergo FDA review. FDA officials said
Qutenza must be applied to the skin by a healthcare profes-
sional since placement of the patch can be quite painful,
requiring use of a local topical anesthetic, as well as ad-
ditional pain relief such as opioid pain relievers. The patch
is manufactured by Lohmann Therapie-Systems AD of Andernach,
Germany, and distributed by NeurogesX Inc. of San Mateo,
Calif.
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Alzheimer's brain changes studied
SAN DIEGO - U.S. medical scientists say they've developed a
fast and accurate method for quantifying subtle brain struc-
ture changes occurring in Alzheimer's patients. The Univer-
sity of California-San Diego researchers said their method
of quantifying sub-regional brain volume loss using magnetic
resonance imaging promises to improve diagnosis and monit-
oring of Alzheimer's disease. By applying the techniques to
the newly completed dataset of the multi institution Alz-
heimer's Disease Neuroimaging Initiative, the researchers
said they demonstrated such sub-regional brain volume meas-
urements outperform available measures for tracking the
severity of Alzheimer's disease. Professor Anders Dale, who
led the study, said the general pattern of brain atrophy
resulting from Alzheimer's disease has long been known, but
exploiting that knowledge toward accurate diagnosis and
monitoring of the disease has only recently been made pos-
sible. He said the study's new methods provide rapid ident-
ification of brain sub-regions combined with measures of
change in the regions across time. "Loss of volume in the
hippocampus is a consistent finding when using MRI, and is
a reliable predictor of cognitive decline," Dale said.
"However, we have now developed and validated imaging bio-
markers to not only track brain atrophy, but distinguish the
early stages of Alzheimer's disease from changes related to
normal aging." The study that included co-author Dr. James
Brewer appears in the Proceedings of the National Academy of
Sciences.
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FDA: Don't use Plavix along with Prilosec
WASHINGTON - The U.S. Food and Drug Administration is warning
patients against using the stomach acid reducer Prilosec with
the anti-clotting drug Plavix. FDA officials said new data
suggests when patients take both Prilosec (omeprazole) and
Plavix (clopidogrel), Plavix's ability to block platelet ag-
gregation, its anti-clotting effect, might be reduced by
about half. Plavix is used to prevent blood clots that could
lead to heart attacks or strokes in at-risk patients, the FDA
said. Omeprazole, the active ingredient of Prilosec, is a
proton pump inhibitor used to reduce the production of stom-
ach acid and prevent stomach irritation. The FDA said Plavix
does not have anti-clotting effects until it is converted or
metabolized into its active form with the help of a liver
enzyme. Prilosec blocks that enzyme, thereby reducing the
effectiveness of Plavix. Officials said it's not known how
other medications might interfere with Plavix. But the FDA
said other drugs that should not be used with Plavix include
Nexium, Tagamet, Diflucan, Nizoral, VFEND, Intelence,
Felbatol, Prozac, Serafem, Symbyax, Luvox and Ticlid. Conver-
sely, the FDA said Zantac, Pepcid, Axid and antacids are not
expected to interfere with the anti-clotting activity of
Plavix.
Postmortem genetic tests to help relatives
ROCHESTER, Minn. - U.S. researchers say postmortem tests to
identify genetic mutations could help relatives at risk of
heart disease and save money. Dr. Michael J. Ackerman of the
Long QT Syndrome Clinic and the Windland Smith Rice Sudden
Death Genomics Laboratory at the Mayo Clinic in Rochester,
Minn., says testing deceased patients can identify mutations
that cause cellular dysfunctions leading to heart rhythm
disturbances and possibly sudden cardiac death. Such inher-
ited genetic defects occur in 25 percent to 30 percent of
victims of sudden unexplained death, said Ackerman, the lead
researcher for the study. The study findings, presented at
the American Heart Association's scientific sessions in Or-
lando, Fla., suggest postmortem testing to identify mutations
associated with sudden cardiac death would be less expensive
than comprehensive cardiac tests for surviving relatives.
Genetic/molecular autopsy testing in 146 cases of sudden
unexplained death showed 40 of the victims had one of two
mutations. Researchers estimated the total cost of doing
postmortem genetic testing, genetic confirmation testing of
relatives of mutation-positive victims, followed by cardiac
tests for both relatives of mutation-positive and mutation-
negative sudden death victims was $6.78 million. In contrast,
the total cost associated with what is currently recommended
and covered by insurance carriers -- comprehensive cardiac
testing for all 584 relatives, regardless of mutation status,
followed by directed genetic testing -- would exceed $7.7
million.
--------------- Health Tip Video of the Week ---------------
Health Tip: The Stages of Sleep
Rating: 3.25
You think you're relaxing, but your body is actually going
through four very distinct stages while you sleep.
http://www.evtv1.com/player.aspx?itemnum=12046
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