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Friday, July 9, 2010
=( THIS WILL BE THE LAST ISSUE OF HEALTH TIPS )=
Retrieval method makes cancer study easier
WEST LAFAYETTE, Ind. - A new retrieval method makes studying
cancer proteins easier, a researcher at Purdue University in
West Lafayette, Ind., said. By using the new technique and a
synthetic nanopolymer, specific proteins can be mapped and
analyzed to find ways to inhibit the processes that lead to
the formation of cancer cells, W. Andy Tao, an assistant
biochemistry professor said Tuesday in a release. The tech-
nique using the synthetic nanopolymer, which Tao developed
and patented, isolates proteins and peptides that have under-
gone a process called phosphorylation, which is closely
associated with cancer, and allows Tao to retrieve those
proteins. Information contained in the proteins is key in
the study of how cancer cells form. "You really want to
capture these particular proteins, but there are so many
different types of proteins around them," said Tao, whose
findings were published in the early online version of
Molecular & Cellular Proteomics. "The target proteins are
a thousand times lower in amount than other proteins. They
are difficult to study without the capturing step." Tao said
he is looking for opportunities to get the polymer and tech-
nique into wider use to help develop new cancer drugs. "This
technique is very useful and can be used widely in research
for cancer as well as infectious diseases," Tao said.
Scientists: 2 antibodies block HIV strains
BETHESDA, Md. - U.S. scientists said Thursday they discov-
ered two potent human antibodies that can stop more than 90
percent of known HIV strains from infecting humans. "The
discovery of these exceptionally broadly neutralizing anti-
bodies to HIV and the structural analysis that explains how
they work are exciting advances that will accelerate our
efforts to find a preventive HIV vaccine for global use,"
Anthony S. Fauci, director of the National Institute of
Allergy and Infectious Diseases, said in a release. "In
addition, the technique the teams used to find the new anti-
bodies represents a novel strategy that could be applied to
vaccine design for many other infectious diseases." Led by
a team from the NIAID Vaccine Research Center, the scien-
tists found two naturally occurring, powerful antibodies
called VRC01 and VRC02 in an HIV-infected individual's blood
using a new molecular device that hones in on specific cells
that make antibodies against the human immunodeficiency vi-
rus. The scientists learned that the two antibodies neutra-
lize more HIV strains with greater overall strength than
previously known antibodies to the virus. They also deter-
mined the atomic-level structure of VRC01 when it is at-
taching to HIV, enabling the team to define how the antibody
works and to precisely locate where it attaches to the
virus, the institute said. "The antibodies attach to a vir-
tually unchanging part of the virus, and this explains why
they can neutralize such an extraordinary range of HIV
strains," said John Mascola, the research center's deputy
director.
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Research light shines on hidden brain lobe
PHOENIX - A scientist at the Barrow Neurological Institute
in Phoenix says he wants to shed light on a lobe of the
brain long hidden from researchers' view. A.D. Craig, who
began studying the often-ignored insula more than 20 years
ago, organized and edited a special edition of the journal
Brain Structure and Function that is dedicated to emerging
medical and scientific interest in the insula, the institute
that is part of St. Joseph's Hospital and Medical Center
said Wednesday in a release. The insula is a prune-sized
area deep within the brain that wasn't studied much because
scientists could not probe the area with surface electrodes,
he said. The advent of sophisticated brain imaging techniques
such as functional magnetic resonance imaging opened the
region to a range of studies. "Rapidly accumulating evidence
indicates that this area of the brain is uniquely involved in
virtually every human emotion and behavior," Craig said.
"Similarly, clinical evidence indicates that it is crucially
involved in a variety of syndromes, including addiction,
anxiety, depression, anosognosia, schizophrenia and fronto-
temporal dementia." Craig said the overall goal of the
special Brain Structure and Function issue on the insula
is to provide a starting point for investigators by identi-
fying issues and opportunities for advances in the knowledge
of this portion of the human brain. "The insula is finally
emerging from its hiding place inside the human brain," Craig
said. "Its central importance to all human feelings and be-
haviors makes it an extraordinarily important target for
potential treatments of many mental dysfunctions, using drugs
or sophisticated biofeedback methods."
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Tylenol Recall Grows Again
The recall of Tylenol and other over-the-counter medicines
has grown once again, with Tylenol maker McNeil PCC Inc.
today announcing the recall of 21 lots of medicines as a
precautionary measure. Today's recall includes Tylenol of
various formulas, including children's Tylenol, the pain-
killer Motrin, and Benadryl allergy tablets. (To find out if
a product you have has been recalled, find the lot number
and go to:
www.mcneilproductrecall.com/page.jhtml?id=/include/prd_all.inc.)
Late last year and into 2010, McNeil recalled a total of
60 million products after an abnormal smell was found in
some containers. The musty, moldy odor was linked to trace
amounts of a chemical called TBA. Today's recall was an-
nounced after an internal review found that some package mat-
erials used in these lots had been shipped and stored on the
same type of wooden pallet tied to the presence of the TBA
in the previously recalled lots, according to a news release
by McNeil.
Find may aid in treating coke addition
JUPITER, Fla. - Scientists in Florida said they uncovered a
natural mechanism controlling cocaine use, suggesting a
potential new method to treat cocaine addition. The Scripps
Research Institute researchers studied the presence of the
molecule, called microRNA-212, in the brains of test animals
with access to cocaine, the institute said in a release. The
findings were published Thursday in in an advance, online
edition of the journal Nature. "The key question that the
study may answer is why one person is more vulnerable to
the effects of cocaine than another," said team leader Paul
Kenny, associate professor in the Department of Molecular
Therapeutics at the Jupiter, Fla., facility. "What we found
is that a specific microRNA exerts enormous control over
the response to the drug. When it is increased in the brain,
it protects against addictive behavior, while a reduction
raises vulnerability to addictive behaviors." The key out-
come of an increased presence of microRNA-212 is "it slams
the brakes on any desire to take the drug," Kenny said. The
findings suggest individuals with serious addiction problems
may have damaged supplies of this particular non-coding RNA,
or the microRNA may not function properly, he said. "Looking
into the future," Kenny said, "It might be possible to de-
velop a small molecule therapeutic that mimics or stimulates
the production of this particular microRNA."
--------------- Health Tip Video of the Week ---------------
Obesity and Gastric Bypass
Rating: 5
Obesity is our number one health problem. Here is the
journey of one woman who lost 140 pounds through gastric
bypass surgery. Her daughter is about to have the same
surgery to avoid having her children grow up with an
obese mother.
http://www.evtv1.com/player.aspx?itemnum=14905
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