Gizmorama - March 5, 2014

Good Morning,

This is remarkable - "In an experiment with mice, U.S. scientists say they've enabled muscle recovery in elderly mice by rejuvenating stem cells within their muscle tissue." Just think of all that can be helped.

Learn about this and more interesting stories from the scientific community in today's issue.

Until Next Time,
Erin

P.S. Did you miss an issue? You can read every issue from the Gophercentral library of newsletters on our exhaustive archives page. Thousands of issues, all of your favorite publications in chronological order. You can read AND comment. Just click GopherArchives

***
*-- Scientists 'rejuventate' stem cells in elderly mice to repair muscles --*
PALO ALTO, Calif. - In an experiment with mice, U.S. scientists say they've enabled muscle recovery in elderly mice by rejuvenating stem cells within their muscle tissue. Normal aging is accompanied by a diminished ability to regain strength and mobility after muscle injury because over time stem cells within muscle tissues dedicated to repairing damage become less able to generate new muscle fibers and struggle to self-renew, researchers at Stanford University reported Sunday. "In the past, it's been thought that muscle stem cells themselves don't change with age, and that any loss of function is primarily due to external factors in the cells' environment," Helen Blau of the university's school of medicine said.."However, when we isolated stem cells from older mice, we found that they exhibit profound changes with age. In fact, two-thirds of the cells are dysfunctional when compared to those from younger mice, and the defect persists even when transplanted into young muscles." However, Blau and her colleagues say they've identified for the first time a process by which the older muscle stem cell populations can be rejuvenated to function like younger cells. "Our findings identify a defect inherent to old muscle stem cells," she said. "Most exciting is that we also discovered a way to overcome the defect. As a result, we have a new therapeutic target that could one day be used to help elderly human patients repair muscle damage." The researchers used drugs to block elevated biological activity within the stem cells that causes them to degenerate into non-stem, muscle progenitor cells. When transplanted back into the animal, the treated, rejuvenated stem cells migrate to their natural niches and provide a long-lasting stem cell reserve to contribute to repeated demands for muscle repair, they researchers said. "In mice, we can take cells from an old animal, treat them for seven days -- during which time their numbers expand dramatically, as much as 60-fold -- and then return them to injured muscles in old animals to facilitate their repair," Blau said.



*-- Orbiting observatory captures images of stars, lunar surface --*
MOFFAT FIELD, Calif. - NASA says an orbiting lunar observation spacecraft successfully downlinked images of the moon and stars taken by onboard camera systems known as star trackers. The main job of the trackers on the Lunar Atmosphere and Dust Environment Explorer (LADEE) is to snap images of the surrounding star field so that the spacecraft can internally calculate its orientation in space, NASA said. But earlier this month they also captures some dramatic views of lunar terrain, scientists said. "Star tracker cameras are actually not very good at taking ordinary images," said Butler Hine, LADEE project manager at NASA's Ames Research Center in Moffett Field, Calif. "But they can sometimes provide exciting glimpses of the lunar terrain." A star tracker is different from ordinary cameras, using lenses with a wide-angle field of view in order to capture the night sky in a single frame. On Feb. 8 while LADEE was carrying out atmospheric measurements the star trackers caught features in the northern western hemisphere of the moon. The observatory successfully downlinked the images, the first time the LADEE team commanded the spacecraft to send such pictures back to Earth, NASA said.

Missed an Issue? Visit the Gizmorama Archives